Daily Chemical
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Tenofovir disoproxil fumarate
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Product description
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Tenofovir disoproxil fumarate [Chinese alias] (R)-9-(2-phosphate methoxypropyl) adenine bis(isopropoxycarbonyloxymethyl) fumarate.
Chinese name
Tenofovir disoproxil fumarate
[Chinese alias] (R)-9-(2-phosphate methoxypropyl) adenine bis(isopropoxycarbonyloxymethyl) fumarate
English name
Tenofovir disoproxil fumarate
[English alias] 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate; bis({[(1-methylethoxy)carbonyl]oxy}methyl) { [(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate
chemical name
(R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid diisopropoxycarbonyloxymethyl fumarate
CAS Number: 202138-50-9
Molecular formula: C23H34N5O14P
Molecular weight: 635.5149
InChI: InChI=1/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4) 11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/ h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2 -1+/t14-;/m1./s1
Boiling point: 642.7°C at 760 mmHg
Flash point: 342.5°C
Solubility: 13.4mg/ml (25℃, water)
Vapor pressure: 2.06E-16mmHg at 25°C
use
Nucleotide reverse transcriptase inhibitors are prodrugs of tenofovir (PMPA, 2) and are mainly used clinically to treat human immunodeficiency virus (HIV) infection.
Physical and chemical properties
This product is white or almost white crystalline powder; odorless. It is easily soluble in dimethylformamide, soluble in methanol; slightly soluble in water and acetonitrile. Melting point 113~118℃
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